H2N2V1, Main, Exploration, bibRecord, 001973

Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene

Identifieur interne : 001973 ( Main/Exploration ); précédent : 001972; suivant : 001974

Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene

Auteurs : Ann H. Reid ; Thomas G. Fanning ; Johan V. Hultin ; Jeffery K. Taubenberger

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1999.

RBID : PMC:15547

Abstract

The “Spanish” influenza pandemic killed over 20 million people in 1918 and 1919, making it the worst infectious pandemic in history. Here, we report the complete sequence of the hemagglutinin (HA) gene of the 1918 virus. Influenza RNA for the analysis was isolated from a formalin-fixed, paraffin-embedded lung tissue sample prepared during the autopsy of a victim of the influenza pandemic in 1918. Influenza RNA was also isolated from lung tissue samples from two additional victims of the lethal 1918 influenza: one formalin-fixed, paraffin-embedded sample and one frozen sample obtained by in situ biopsy of the lung of a victim buried in permafrost since 1918. The complete coding sequence of the A/South Carolina/1/18 HA gene was obtained. The HA1 domain sequence was confirmed by using the two additional isolates (A/New York/1/18 and A/Brevig Mission/1/18). The sequences show little variation. Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15547

PubMed: 9990079
PubMed Central: 15547

Affiliations:

Le document en format XML

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<author><name sortKey="Fanning, Thomas G" sort="Fanning, Thomas G" uniqKey="Fanning T" first="Thomas G." last="Fanning">Thomas G. Fanning</name>
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<author><name sortKey="Hultin, Johan V" sort="Hultin, Johan V" uniqKey="Hultin J" first="Johan V." last="Hultin">Johan V. Hultin</name>
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<author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
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<front><div type="abstract" xml:lang="en"><p>The “Spanish” influenza pandemic killed over 20 million
 people in 1918 and 1919, making it the worst infectious pandemic in
 history. Here, we report the complete sequence of the hemagglutinin
 (HA) gene of the 1918 virus. Influenza RNA for the analysis was
 isolated from a formalin-fixed, paraffin-embedded lung tissue sample
 prepared during the autopsy of a victim of the influenza pandemic in
 1918. Influenza RNA was also isolated from lung tissue samples from two
 additional victims of the lethal 1918 influenza: one formalin-fixed,
 paraffin-embedded sample and one frozen sample obtained by <italic>in
 situ</italic> biopsy of the lung of a victim buried in permafrost since
 1918. The complete coding sequence of the A/South Carolina/1/18
 HA gene was obtained. The HA1 domain sequence was confirmed by using
 the two additional isolates (A/New York/1/18 and A/Brevig
 Mission/1/18). The sequences show little variation. Phylogenetic
 analyses suggest that the 1918 virus HA gene, although more closely
 related to avian strains than any other mammalian sequence, is
 mammalian and may have been adapting in humans before 1918.</p>
</div>
</front>
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<tree><noCountry><name sortKey="Fanning, Thomas G" sort="Fanning, Thomas G" uniqKey="Fanning T" first="Thomas G." last="Fanning">Thomas G. Fanning</name>
<name sortKey="Hultin, Johan V" sort="Hultin, Johan V" uniqKey="Hultin J" first="Johan V." last="Hultin">Johan V. Hultin</name>
<name sortKey="Reid, Ann H" sort="Reid, Ann H" uniqKey="Reid A" first="Ann H." last="Reid">Ann H. Reid</name>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
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Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene

Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene

Source :

Abstract

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